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Before the study began, all patients had magnetic resonance imaging (MRI) to evaluate brain structure and volumes, glucose metabolism PET scans and detailed memory testing

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The novel triple-agonist mechanism means less long-term safety data is available

You might notice weight loss is faster at higher doses studies did find the highest doses yielded the greatest average weight loss but remember, a lot of groundwork is laid at the lower doses too (and some people even lose a lot at the lower doses because they diligently changed their lifestyle from the get-go)